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Kratom is relatively new botanical within the US and Europe, but has been used for many years in Southeast Asia. Kratom is the popular name for this tree’s leaves, (also known as Mitragyna Speciosa). The botanical may be bought in leaf form in this country, but is more likely to be purchased as a capsule filled with powdered leaf material or a ground form of the leaf.

Recent News & Updates

  • Pharmacological Studies on 7-Hydroxymitragynine, Isolated from the Thai Herbal Medicine Mitragyna speciosa: Discovery of an Orally Active Opioid Analgesic

    Substances derived from natural products have been utilized since the beginning of time for various medical purposes including the treatment of pain. Opium, for example, has been mentioned in the earliest historical records, some 7000 years ago. In fact, research in the area of pain management and drug addiction originally focused on natural products exclusively. […]

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  • Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

    The opioid receptors, and in particular, the mu-opioid receptor (MOR), are among the longest and most intensely studied molecular signaling systems in the central nervous system.1 Likewise, the prototypical small molecule agonist of these receptors, morphine, has been used by humans as an important analgesic and recreational euphoriant since ancient times. Indeed, MOR agonists, including […]

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  • In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

    In the present study, we investigate the effects of three different Mitragyna speciosa extracts, namely methanolic, aqueous and total alkaloid extracts, on glutathione transferase-specific activity in male Sprague Dawley rat liver cytosol in vitro and in vivo. In the in vitro study, the effect of Mitragyna speciosa extracts (0.01 to 750 µg/mL) against the specific […]

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